Decrease in physical fitness in the survivors of childhood Leukemia

The best indicator of aerobics physical fitness, as recommended by WHO , is the peak oxygen update attained during a graded maximum exercise to volitional exhaustion.
Peak oxygen uptake is, Volume of Oxygen consumed per unit of time relative to body mass. This is a good indicator of health status and predicts mortality rate in both healthy and diseased persons. Improve quality of life reflects exercise capacity and VO2 peaks. That is normal activities can be carried out with no fatigue.
VO2 levels lowers in adult cancer patients, due to poor physical conditions. Studies shows there is decrease in VO2 peak in the survivors of acute lymphoblastic leukemia. So exercise training prescription is necessary to improve their work capacity.
Decrease in VO2 peak are largely attributable to impaired cardiac function as it mainly reflects maximal O2 supply to muscles rather than maximal rate of O2 utilization by muscles mitochondria.
Anticancer therapy and sedentary habits decrease cardiac output which can be improved by exercised based therapy. Different lung infections can also reduce lung capacity.
So impaired physical fitness leads to early fatigue during physical activities and can severely deteriorate the quality of life.
Studies shows these children should be engage in regular physical exercise. Also there are scientific indications that exercise training improves the function of several ant cancer immune system components.